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Title   인체 페선암종에서의 Phospholipase D 와 금속단백 효소 및 조직 내 효소억제자의 발현 ( Expressions of Phospholipase D, MMP-2, and TIMP-2 in Adenocarcinomas of the Lung )
Publicationinfo   2000 Jan; 032(02): 398-407.
Key_word   Lung neoplasm, Phospholipase D, Gelatinase A
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Abstract   Purpose: Metastatic spread depends critically upon the invasiveness of tumor cells, i.e. their ability to breach basement membranes by elaborating and secreting specific proteolytic enzymes such as gelatinase A (MMP-2). Phospholipase D (PLD) is believed to play an important role in cell proliferation and tumorigenesis. Also several studies suggested that activation of PLD and consequent generation of phosphatidic acid are involved in signal propagation pathway leading to induction of MMP-2. However, the relation between PLD and MMP-2 is not fully studied in lung cancer tissue, yet. Materials and Methods: Adenocarcinomas of the lung from 20 patients were studied for immunohistochemical expressions of PLD, MMP-2 and TIMP-2 to assess their diagnostic and prognostic importance in lung tumors. Results: With decreasing tumor differentiation, there was a progressive increase of MMP-2 and PLD and TIMP-2 expression decreased. Type IV collagenase expression was significantly associated with the presence of lymph node metastases, with moderate to strong expression, presented in 60% node positive tumors compared with none of the node negative tumors (p < 0.05). PLD was increased in tumor (strong: 60%) with nodal metastases compared with those without nodal metastases (p < 0.05), Increase of MMP-2 and PLD expression was associated with loss of TIMP-2 expression. Conclusion: In correlation expression of the immunohistochemical markers and invasion, PLD as well as type IV collagenase and TIMP2 expressions was found to be a predictor of invasiveness. Measurable alterations in MMP-2 and TIMP-2 and in particular, expression of PLD may be an important factor to assess invasiveness in resectable adenocarcinoma of the lung.
저 자   박재후(Jae Hoo Park),이기만(Ki Man Lee),신재균(Jae Kyun Shin),박상규(Sang Kyu Park),김효경(Hyu Kyung Kim),김성숙(Sung Sook Kim),임소덕(So Duk Lim),허주령(Joo Ryung Huh),노재윤(Jae Yoon Roh),서판길(Pann Ghil Suh),유성호(Sung Ho Ryu)